Phentermine and Sibutramine are drugs to treat exogenous obesity, including patients with diabetes, dyslipidemia and (or) controlled hypertension. Phentermine and Sibutramine medications are produced by several pharmaceutical companies, so they are sold under different trade names at pharmacies.
- The most known trade names of Phentermine medication are Duromine (in Australia) and Adipex (in the U.S.).
- Sibutramine medication is better known under the trade names Reductil (in Australia) and Meridia (in the USA).
Mechanism of Sibutramine action
Sibutramine drug for weight loss has pharmacological property to inhibit serotonin-norepinephrine reuptake from the synaptic cleft of the hypothalamus. Sibutramine enhances the interaction between norepinephrine and serotonergic systems, thereby suppressing the appetite and increasing thermogenesis.
Mechanism of Phentermine action
Phentermine drug for obesity treatment affects hypothalamus which stimulates adrenal glands to produce norepinephrine, by enhancing a feeling of satiety. By interacting with noradrenaline neurotransmitters, Phentermine not only suppresses the appetite but also partially burns fatty deposits. Phentermine drug for appetite suppression also interacts with dopamine and serotonin neurotransmitters (to a lesser extent).
Contraindication for Phentermine and Sibutramine use
Contraindications for Sibutramine use to treat exogenous obesity almost coincide with contraindications for Phentermine use to suppress the appetite.
Use of Phentermine and Sibutramine medications are contraindicated in: cardiovascular diseases; glaucoma; pulmonary hypertension; arterial hypertension; hyperthyroidism; simultaneous use with other drugs for weight loss; serotonin reuptake inhibitors (Paroxetine, Fluoxetine, Fluvoxamine, Sertraline); MAOIs use (Iproniazid; Moclobemide; Metralindole; Selegiline).
Phentermine pills and Sibutramine pills should not also be taken: during pregnancy and breastfeeding; in children (under 16 years); in elderly patients (over 65 years).
In contrast to Sibutramine drug which is contraindicated in anorexia nervosa, bulimia, severe liver or kidney dysfunction, Phentermine drug may be prescribed to treat obesity in patients with eating disorders and patients with liver or kidney failure.
Sibutramine and Phentermine diet pills mode of application
Phentermine and Sibutramine medications for exogenous obesity treatment are prescribed for short-term obesity pharmacotherapy. Do not use slimming pills Sibutramine and slimming pills Phentermine after 6 p.m. to avoid an insomnia development.
- For effective weight loss, most obese patients are recommended to take a single daily dose of Phentermine 30mg (one Phentermine 30mg pill once daily).
- For most obese patients an optimal daily dose of Sibutramine is 10mg (one Sibutramine 10mg pill once daily).
If after taking Sibutramine or Phentermine within 12 weeks, body mass has not decreased by 5% (and more), the course of obesity treatment should be stopped. Repeat course of obesity treatment can be conducted at least 3 months after taking the last dose of Phentermine (or Sibutramine).
If you decide to conduct repeat course of obesity treatment but prescription validity term for Phentermine pills (or Sibutramine pills) has already expired, on our online pharmacy you can order a delivery of medications for obesity treatment online. You can order Phentermine medication and (or) Sibutramine online from any country in the world.