Phentermine vs Orlistat

Phentermine and Orlistat are two most popular drugs in the world that are used for reduction of extra weight and for the fight against obesity. These drugs can fight obesity very effectively, but each of them has different pharmacological effect on a patient’s body. Read more


Phentermine vs Fastin

To cure obesity, different types of drugs are used, for instance, appetite suppressants or gastrointestinal lipase inhibitors. Phentermine and Fastin are the appetite suppressants, used for a short-term treatment of excess weight and obesity. Read more


Phentermine and Topiramate

Qsymia (Phentermine and Topiramate)

July 17, 2012 the FDA approved a new drug Qsymia for obesity treatment. The new drug Qsymia for obesity treatment consists of two pharmacological substances Phentermine and Topiramate.

  • Phentermine was approved by the FDA for short therapy of exogenous obesity.
  • Topiramate was approved by the FDA for the treatment of epileptic attacks and prevention of migraine.

Feasibility of combined use of Phentermine and Topiramate is proven by the fact that Topiramate has anorexigenic effect just as Phentermine. Therefore Topiramate increases pharmacological action of Phentermine, allowing to reduce the dose of Phentermine twice.

It should be noted though that Topiramate possesses slight anorexigenic effect and even maximal Topiramate doses provide no significant effect. Hence, Topiramate cannot be prescribed for monotherapy of obesity and can be only used in combination with Phentermine.

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Phentermine vs Celexa

Phentermine is anorexigenic drug, prescribed for obesity treatment. In different countries Phentermine is available under different trade names (including Adipex).

Celexa is a trade name of Citalopram antidepressant that is a selective serotonin reuptake inhibitor (SSRI). Celexa (Citalopram) drug for the treatment of depressive disorders is produced by Forest Laboratories.

Phentermine Mechanism of Action

Phentermine anorexigenic drug stimulates the release of norepinephrine and dopamine by the nerve endings in hypothalamus saturation center. While working on those brain parts that are responsible for appetite, Phentermine relieves hunger sensation. Therefore when using Phentermine, the amount of consumed food reduces and so the body starts to lose weight.

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Phentermine vs Sibutramine

Phentermine and Sibutramine are drugs to treat exogenous obesity, including patients with diabetes, dyslipidemia and (or) controlled hypertension. Phentermine and Sibutramine medications are produced by several pharmaceutical companies, so they are sold under different trade names at pharmacies.

  • The most known trade names of Phentermine medication are Duromine (in Australia) and Adipex (in the U.S.).
  • Sibutramine medication is better known under the trade names Reductil (in Australia) and Meridia (in the USA).

Mechanism of Sibutramine action

Sibutramine drug for weight loss has pharmacological property to inhibit serotonin-norepinephrine reuptake from the synaptic cleft of the hypothalamus. Sibutramine enhances the interaction between norepinephrine and serotonergic systems, thereby suppressing the appetite and increasing thermogenesis.

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