It is easier to cope with such disease as obesity at the early stage of its development. The initial stage of obesity is called exogenous and it is often occur because of overeating.

Ionamin – is one of the drugs, which helps to get rid of exogenous obesity.

The main component is long-acting Phentermine resin, which has a selective effect on parts of the brain responsible for appetite.

Effects

After absorption into the obese patient’s body, Phentermine stimulates the work of nervous system and increases blood pressure.

Tachyphylaxis and other permissible variations are observed in people taking Ionamin and other drugs of this class.

  • Drugs like Ionamin used for obesity treatment are known under the general name “anorectics”.

Nevertheless, it was not reliably established that obesity treatment by such drugs is aimed primarily at appetite suppression.

  • When using the drug containing Phentermine, an intensive metabolism occurs in the obese patient’s body. However, rapid metabolism may lead to increased appetite and, as a consequence, to overeating.

Clinical trials have demonstrated that obese patients taken anorectic drugs have lost more extra pounds than patients treated only with diet therapy.

The main properties of obesity have been studied for many years, while research data presented here is limited to a few weeks or months. Thus, positive effect of drug treatment of obesity without diet therapy is not complete.

Phentermine bioavailability was studied on obese patients, whose Phentermine level in the blood was measured by gas chromatography. In the dosage of 15 mg and 30 mg Phentermine base, it was revealed a slow penetration into the blood, but a long period of concentration.

Before And Afte

But the same doses of Phentermine hydrochloride are dissolved in the blood more intensively, however, duration of Phentermine hydrochloride action is shorter. This is the advantage of Phentermine base over Phentermine in the form of hydrochloride.

Recommendations for use

Ionamin is intended as short-term use within a few weeks. Along with the medication use, exercise and low-calorie diet are recommended. This drug is also recommended for patients with exogenous obesity with BMI ≥ 30 kg / m2 or ≥27 kg / m2 in availability of such diseases as hypertension, diabetes, or hyperlipidemia.

Ionamin is recommended only as a means for exogenous obesity.

  • Do not take Ionamin simultaneously with:
Other drugs for weight loss (Orlistat, Rimonabant, Metformin)
Antidepressants promoting metabolism (Fluoxetine, Sertraline, Fluvoxamine, Paroxetine)
Drugs of CNS group (Venlafaxine, Mexidol, Risperidone)

When applying Phentermine, there is a risk of toxic reaction of this active substance on the kidneys. Therefore, the drug dose should be individually chosen for patients with acute tubular necrosis.

Ionamin should be prescribed with caution to patients even with non-acute form of hypertension. Requirements to insulin use during treatment with Ionamin can be changed due to undesirable interaction of these two drugs.

Contraindications

Phentermine is contraindicated in patients with atherosclerosis, diseases of the cardiovascular system, moderate to severe hypertension and glaucoma. In addition, the drug should not be taken in individual hypersensitivity of the body.

If a patient failed to lose weight while taking Phentermine, the recommended dose should not be increased. In this case, it is better to stop taking the drug.

Side effects

The use of drugs with active ingredient Phentermine may be accompanied with occurrence of side effects. Such adverse reactions as increased blood pressure, headache, irritability, insomnia and dry mouth may often arise.

Rare, often fatal lung disease – Primary Pulmonary Hypertension (PPH) has been observed in patients who were taking Phentermine with Fenfluramine amphetamine stimulant or Dexfenfluramine serotoninergic anorectic drug.

Link between PPH occurrence and the use of Phentermine alone cannot also be excluded. Normally, initial symptoms of PPH are shortness of breath, fainting and swelling of the lower extremities.

  • If patients have these symptoms, the use of Phentermine should be stopped immediately.

Patients who took Phentermine in combination with sympathomimetic stimulant Fenfluramine or serotonergic anorectic drug Dexfenfluramine were reported to have serious diseases of the heart valves. The causes of these diseases while taking Phentermine are unknown.

Ionamin can affect the patient’s ability to drive a vehicle. Therefore, the treating physician is obliged to warn in advance about possible consequences of the drug use.

Always remember that Phentermine is a CNS-active substance, so abstain from consumption of any amount of alcohol.

Ionamin is similar to amphetamine and other drugs by its chemical and pharmacological properties. By assigning the drug, the attending physician should take into account that abuse of active ingredient Phentermine may cause drug addiction.

Use during pregnancy and age limits

Clinical trials of Ionamin have not established the drug effect on the body during pregnancy.

  • When prescribing the medicine, the attending physician is obliged to warn the pregnant woman about the possible negative consequences for her health and for unborn baby’s health. Moreover, the use of Phentermine is not recommended for adolescents under 16 years of age.

There are no age limitations in Ionamin application. Effect of the drug on obese patients over 65 years and younger patients were about the same. Exception is patients with renal insufficiency.

Dosage

Ionamin capsules should be swallowed whole with water. Frequency of drug administration is a capsule per day before breakfast or 10-14 hours before bedtime.

Phentermine 15 mg capsules are sufficient for people with high sensitivity to effects of CNS stimulants. Patients with less sensitivity can use Phentermine 30 mg capsules.

Do not increase the dose of the drug.

It should also be noted that sudden discontinuation of the drug may be accompanied with various degree of fatigue and even depression. In systematic abuse of the drug, insomnia, dermatoses, bouts of hyperactivity were observed in patients. When taking Ionamin, obese patients developed psychosis often indistinguishable from schizophrenia.

In severe overdose, such adverse effects as hallucinations, arrhythmia or vomiting may occur. In severe cases, the use of Phentermine led to acute poisoning and even coma.

In systematic use of drugs with active ingredient Phentermine, a significant improvement in health status and significant weight loss are observed in obese patients.

However, it should be noted that treatment only by means of the drug would not bring the desired result. Treatment of exogenous obesity should be combined with diet therapy and physical activity.